Mauricio Pochettino insisted his job does not include pleading with his players to stay at the club.
Several Tottenham stars were linked with summer transfers, including defensive duo Toby Alderweireld and Danny Rose.
Manchester United were monitoring both players, while Rose weighed up a loan switch abroad with Schalke and Paris Saint-Germain reportedly interested.
Alderweireld and Rose were not lured away despite interest from other clubs, but Pochettino says any player who wants to leave should do so.
I am not a person who is going to convince players to stay or not stay, said Pochettino.
If they want to leave, they want to leave. The players who dont want to stay can leave. Im not going to convince people to stay who dont want to.
Its not a problem if we lose one or two or three. Because we have plenty of players in the academy, no problem.
I am more than happy to keep all the players and I am more than happy if they leave, and we play with the under-23s. Its not a problem, I promise you. Not a problem for me.
Alderweireld and Rose are both flying high after playing in the 3-0 win over United at Old Trafford.
Tottenham will aim to continue their 100 per cent start to the season with an away trip at Watford on Sunday.
Spurs share top spot in the Premier League with fellow unbeaten sides Watford, Liverpool and Chelsea.