City’s quest for an unprecedented quadruple lives on as their magnificent season continues across every competition they are competing in.
They face a Wigan side who are battling for promotion at the top of the League One table.
The Latics were beaten 2-0 at home to Blackpool to drop below Shrewsbury Town, however, they remain in a strong position with two games in hand over Blackburn Rovers, level on points in third place.
The former FA Cup champions defeated Bournemouth and West Ham en route to the fifth round.
Wigan defeated City to win the competition in 2013.
What time is Wigan vs Man City kick-off?
Kick-off is at 7.55pm on Monday 19 February at DW Stadium.
What TV channel is Wigan vs Man City on?
The match will be shown live on BBC One, with coverage starting from 7.30pm.
Viewers based in the UK will able to stream the match online via BBC iPlayer and the BBC Sport website.
Claudio Bravo could return in goal as he has featured in domestic cup matches this season.
Leroy Sane and David Silva could continue their comebacks from injury after substitute appearances in midweek.
Gabriel Jesus (knee) has returned to training, but the game will come too soon for him and Benjamin Mendy (knee) is still a long-term absentee.
Wigan will be without Devante Cole, Donervon Daniels and James Vaughan who are all cup-tied.
However, former Manchester United forward Nick Powell and striker Will Grigg will lead the attack.
Midfielder Sam Morsy is suspended.
What are the odds? (Courtesy of Betfair)
Wigan – 17-1
- This is the fifth meeting between these two sides in the FA Cup, with Wigan winning each of the last two (L2), including an FA Cup final victory thanks to Ben Watson’s goal in 2013.
- The Latics have only lost one of their 10 FA Cup matches against top-flight opposition (W7 D2), progressing past Premier League sides in rounds three and four this season.
- Sergio Aguero has scored 16 goals in 17 FA Cup games for Man City since his debut in the competition in January 2012; three more than any other player in the competition in that time.