Doctors treating Russian opposition figure Alexei Navalny say he is out of an induced coma and his condition, since being poisoned, has improved.
He is responding to verbal stimuli, they said. Mr Navalny, 44, was flown to Germany after falling ill on a flight in Siberia in August.
His team allege he was poisoned on the orders of Russian President Vladimir Putin, who denies any involvement.
German doctors say the Putin critic was poisoned with a Novichok nerve agent.
On Monday, the Charité hospital in Berlin said in a statement that Mr Navalny was being weaned off mechanical ventilation.
"He is responding to verbal stimuli. It remains too early to gauge the potential long-term effects of his severe poisoning," it said.
It also said doctors were in close contact with Mr Navalny's wife.
Mr Navalny's spokeswoman, Kira Yarmysh, tweeted: "News about Alexei. Today he was taken out of induced coma. Gradually he will be switched off from a ventilator. He responds to speech and to being addressed to."
What happened to Alexei Navalny?
Mr Navalny fell ill on 20 August on a flight from Tomsk to Moscow. His supporters suspect poison was placed in a cup of tea at Tomsk airport.
"Alexei started moaning and screaming. He was clearly in pain. He was lying on the floor in the part of the plane reserved for cabin crew," a passenger seated near Mr Navalny on the plane told BBC Russian.
The plane was diverted to Omsk, where the opposition politician was admitted to an emergency hospital. Russian officials initially refused to allow Mr Navalny to be transferred abroad for medical treatment but after three days he was flown by air ambulance to Berlin.
Last week, doctors in Germany said the results of toxicology tests carried out at a military laboratory gave "unequivocal proof" that Mr Navalny was poisoned with a Novichok nerve agent.
Doctors in Omsk insisted that no poisonous substances had been detected in Mr Navalny's body when he was under their care.
On Monday, the Kremlin said it was "absurd" to blame Russia for Mr Navalny's poisoning. "Attempts to somehow associate Russia with what happened are unacceptable to us, they are absurd," Mr Putin's spokesman, Dmitry Peskov, said.
Russian foreign ministry spokeswoman Maria Zakharova said the allegation that Novichok was used was not backed up by evidence.
A Novichok nerve agent was used to poison former Russian spy Sergei Skripal and his daughter in the UK in 2018. A UK investigation blamed the Russian state.
What is Navalny known for?
Mr Navalny is an anti-corruption campaigner who has led nationwide protests against the Russian authorities. He first emerged as a blogger in 2008 and has in recent years become the most prominent opposition politician in Putin's Russia.
He has called Mr Putin's party a place of "crooks and thieves" that is "sucking the blood out of Russia", and has faced attacks in the past.
However, he has been banned from standing against Mr Putin in recent elections because of a conviction for embezzlement. He denies the crime, saying his legal troubles are Kremlin reprisals for his fierce criticism.
What's the international reaction?
On Monday, the British government summoned the Russian ambassador to the UK "to register deep concern about the poisoning".
"It's completely unacceptable that a banned chemical weapon has been used and Russia must hold a full, transparent investigation," Foreign Secretary Dominic Raab said on Monday..
In Germany there is growing pressure for Chancellor Angela Markel to take a tougher stance over the incident. Last week, she said Mr Navalny was the victim of attempted murder and that the world would look to Russia for answers.
For the first time, the German government is no longer ruling out stopping the construction of the controversial Nord Stream 2 pipeline, says the BBC's Damien McGuinness in Berlin.
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